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CoQ10 supplementation significantly improves endothelial function, meta-analysis shows


  • Meta-analysis of 5 randomized, controlled clinical trials involving 194 patients
  • Subjects include patients with and without established cardiovascular disease
  • CoQ10 dosages range from 150 to 300 mg/day; study durations from 4 to 12 weeks
  • CoQ10 supplementation significantly improves endothelial function


This meta-analysis was designed to quantify the effect of co-enzyme Q10 (CoQ10) on endothelial function in patients with and without established cardiovascular disease.

Study inclusion criteria included randomized clinical trials published in the peer-reviewed literature up to July 1, 2011. Eligible studies were randomized, placebo-controlled trials on the effects of coenzyme Q10 on endothelial function. Five studies met the inclusion criteria involving 194 patients. CoQ10 dosages ranged from 150 to 300 mg/day; study durations ranged from 4 to 12 weeks.

Meta-analysis using random-effects model showed CoQ10 supplementation significantly improved endothelial function as assessed peripherally by flow-mediated dilatation (FMD), but not as assessed by nitrate-mediated arterial dilatation (NMD). In all the individual studies, except one with the lowest dosage (150 mg/day for 8 weeks), CoQ10 showed a statistically significant effect on FMD. When compared to placebo, CoQ10 therapy significantly improved %FMD by 1.70% (95% CI: 1.00-2.40; P<.00001). This has clinical relevance as the author’s note that an absolute improvement in FMD of 1% may translate into a 10-25% reduction in residual cardiovascular risk for these patients. No significant heterogeneity for this outcome was found. CoQ10 supplementation did not significantly improve %NMD compared to control, suggesting no effect on endothelium-independent vasorelaxation. No significant heterogeneity was found for this outcome as well.

These findings indicate that short-term CoQ10 supplementation (150-300 mg/day) is associated with significant improvement in endothelial function and may offer clinical value for patients with endothelial dysfunction.


Gao L, Mao Q, Cao J, Wang Y, Zhou X, Fan L. Effects of coenzyme Q10 on vascular endothelial function in humans: a meta-analysis of randomized controlled trials. Atherosclerosis. 2012;221(2):311-6. Review.

PMID: 22088605