Request Clinical Starter Kits for Your Patients Today! Request Now

Are you a clinician?

This is a clinician-only website.
By entering, you acknowledge that you're a clinician.

Extended-release wax-matrix nicotinic acid supports LDL and HDL cholesterol metabolism, study shows


  • Randomized, double-blind, placebo-controlled, crossover trial (n= 40 men and women)
  • Extended-release, wax-matrix nicotinic acid supports LDL and HDL cholesterol metabolism
  • Effective amounts range from 1,500-2,000 mg/day


This 6-month, randomized, double-blind, placebo-controlled, crossover trial, completed by researchers at the National Research Center for Preventive Medicine, Moscow, Russia, investigated the therapeutic effect of ENDUR-ACIN® for dyslipidemia.

For this study, researchers enrolled 40 men and women, aged 35 to 70 years, with high blood cholesterol (225-300 mg/dl) after following a heart healthy diet for 2 months. Patients received extended-release wax-matrix nicotinic acid (WMNA) in dosages of 1,500-2,000 mg/day. Total, HDL-, and LDL-cholesterol and triglyceride were assessed.

Of the 40 patients, 75% (30/40) were responsive to treatment based on reduction in LDL-cholesterol. In the non- responsive group no significant changes occurred in lipid variables. In the responsive group, significant improvements from baseline were reported for total cholesterol, LDL and HDL cholesterol as follows:

  • Total Cholesterol: 17% decrease (257+3.5 to 213+4.1 mg/dl)
  • LDL Cholesterol: 27% decrease (183+5.0, to 133+5.9 mg/dl)
  • HDL Cholesterol: 17% increase (47+2.6 to 55+2.8 mg/dl)

The ability of WMNA to improve total, LDL- and HDL-cholesterol levels indicates that it has therapeutic benefits for patients with hypercholesterolemia as well as patients with low HDL-cholesterol.


Kisseleva N, et al. Specific lipid response to wax-matrix sustained-release niacin treatment in patients with hypercholesterolemia. Atherosclerosis. 1999;144S1:S23.

Disclaimer: This information is for licensed healthcare professionals only to inform patient treatment. It is not intended for consumer use.