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EVNol SupraBio™ mixed tocotrienols reduces high blood cholesterol in adults, study shows


  • EVNol SupraBio™ mixed tocotrienols significantly reduces total and LDL cholesterol in adults with high blood cholesterol
  • Effective dosage is 300 mg/day for at least 4 months
  • Treatment is well tolerated


This randomized, placebo-controlled study was designed to investigate the cholesterol-lowering activity of EVNol SupraBio™ mixed tocotrienols in adults with high blood cholesterol.

For this study, researchers recruited 32 hypercholesterolemic, but otherwise healthy, participants (20 men and 12 women), aged between 31 and 53 years, who were not taking any drugs that affect blood lipid profiles. All participants had initial baseline serum total cholesterol levels of >6.2 mmol/L, LDL-cholesterol >4.0 mmol/L and triglycerides >3.8 mmol/L.

The participants were randomly assigned to take either EVNol Suprabio™ mixed tocotrienols* (300 mg/day) or a placebo for 6 months. The participants were monitored before supplementation and monthly thereafter for their serum cholesterol, tocotrienol and tocopherol levels. All participants complete the study and no adverse events were reported

Supplementation resulted in a 22-fold increase in total tocotrienol levels from baseline, compared to placebo, but only a modest increase in alpha-tocopherol was reported.

Supplementation also significantly (P<.05) reduced total cholesterol and LDL cholesterol after 4 months (-8.9±0.9% and -12.8±2.6%, respectively) and after 6 months (-10.8±1.0% and -17.3±1.8%, respectively). Conversely, placebo had no effect on the serum cholesterol, total tocotrienol and alpha-tocopherol levels.

No adverse events were reported, indicating supplementation was well tolerated.

These findings indicate that supplementation with EVNol SupraBio™ mixed tocotrienols (300 mg/day) for at least 4 months significantly lowers elevated serum total and LDL cholesterol levels and is well tolerated.

*The study treatment is identified as TOCOVID SupraBio™ softgels, which is another brand name for EVNol SupraBio™ softgels. EVNol SupraBio is a trademark of ExcelVite Inc and protected by US Patent No – 6,596,306 and 7,211,274.


Yuen KH, Wong JW, Lim AB, Ng BH, Choy WP. Effect of mixed-tocotrienols in hypercholesterolemic subjects. Funct Foods Health Dis. 2011:3:106-117