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Dihydroberberine SR 150 mg

Available exclusively through licensed healthcare practitioners at the following online dispensaries:


      May help:

      • Maintain healthy blood glucose in the normal range*
      • Promote healthy cholesterol & lipid metabolism*
      • Support blood vessel health*
      • Eliminate digestive upset that can occur with regular berberine

      Sustained release (5-7 hours)

      Product Description

      Dihydroberberine SR 150mg is ideal for men and women who want an effective nutritional therapy for glucose balance, lipid metabolism and cardiovascular health that is both well-tolerated and convenient. Formulated to complement doctor-recommended diet and lifestyle changes.*

      Dihydroberberine SR 150mg is a sustained-release dietary supplement featuring GlucoVantage® dihydroberberine, a highly bioavailable form of berberine. Once absorbed by the intestine, dihydroberberine rapidly converts to berberine in the blood.(1)

      Berberine has been widely studied in pre-clinical and clinical studies. It’s ability to positively affect glucose balance, lipid metabolism and blood vessel health is attributed to multiple actions. For example:

      • Glucose Balance. Results from pre-clinical studies indicate berberine activates a key biochemical pathway – the AMP-activated protein kinase (AMPK) pathway – that plays a role in glucose uptake by tissues.(2)
      • Lipid Metabolism. Results from pre-clinical studies indicate berberine promotes healthy cholesterol metabolism by a variety of actions. First, it upregulates LDL-receptors on liver cells that shuttle cholesterol out of the blood and into cells. Berberine inhibits intestinal cholesterol absorption and increases excretion as well as provides antioxidant defense. By activating AMPK, it also increases fatty acid oxidation (burning) and decreases fatty acid synthesis.(3)

      • Blood Vessel Function. Results from pre-clinical studies indicate berberine promotes healthy endothelial function, an action attributed in part to its ability to reduce oxidative stress.(4)

      As a highly bioavailable form of berberine, Dihydroberberine SR may help maintain healthy blood glucose and lipid levels in the normal range while supporting vascular health.*


      • Easy-to-swallow tablets
      • No salt, sugar, starch, artificial flavors, colors, sweeteners or preservatives
      • Gluten-free
      • Vegan/Vegetarian
      • Free of common allergens (milk, egg, fish, shellfish, soy, peanuts, tree nuts and wheat)
      • Sustained release (5-7 hours)


        Frequently Asked Questions

        What can you expect?
        Dihydroberberine SR
        provides targeted nutritional support for glucose balance, lipid metabolism and cardiovascular health.*

        How does it work?
        Dihydroberberine SR
        is a sustained-release dietary supplement. By using a proprietary vegetable wax matrix core, each tablet delivers 150mg of highly bioavailable GlucoVantage® dihydroberberine with a steady release over 5 to 7 hours.*

        How do you take it?
        As a dietary supplement for adults, take one (1) tablet, twice daily with food, or as directed by a healthcare professional.

        What are the inactive ingredients?
        The inactive ingredients include: Vegetable wax (rice bran and/or carnauba), isomalt (vegetable), stearic acid (vegetable), magnesium stearate (vegetable), and silica.

        How does dihydroberberine overcome absorption challenges of berberine?
        Researchers attribute the superior absorption of dihydroberberine to two key pathways (see Figure). In Pathway 1, berberine is slowly absorbed, but a carrier protein (P-glycoprotein) shuttles some of it back into the intestine. In Pathway 2, gut bacteria that produce nitroreductases (NTR) can convert berberine into the more absorbable dihydroberberine form. However, this pathway is limited in people who lack an adequate amount of NTR-producing gut bacteria. Dihydroberberine overcomes both of these absorption challenges. In one comparison study, absorption was found to be almost 5 times higher than berberine absorption and, once absorbed, dihydroberberine is rapidly oxidized into berberine in blood.(1)



        Are there any precautions?
        Consult your healthcare professional prior to use if you have or suspect a medical condition or are taking any medications. Do not use without the advice of your physician if you have diabetes or a related condition as dihydroberberine may lower blood sugar. Do not use if you are pregnant, planning to become pregnant, or nursing.

        What product quality control tests are performed?
        Dihydroberberine SR
        is manufactured in the United States (Oregon) in a state-of-the-art, FDA-registered facility that meets or exceeds current Good Manufacturing Practices (cGMP). Quality control tests are performed at every stage of the manufacturing process from rigorous raw material testing to finished product testing.


        1. Feng R, Shou JW, Zhao ZX, et al. Transforming berberine into its intestine-absorbable form by the gut microbiota. Sci Rep. 2015;5:12155. PMID: 26174047.
        2. Yin J, Ye J, Jia W. Effects and mechanisms of berberine in diabetes treatment. Review. Acta Pharm Sin B. 2012:2(4):327-334.
        3. Cicero AFG, Colletti A, Bajraktari G, et al. Lipid lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel. Arch Med Sci. 2017;13(5):965-1005. PMID: 28883839.
        4. Firouzi S, Malekahmadi M, Ghayour-Mobarhan M, Ferns G, Rahimi HR. Barberry in the treatment of obesity and metabolic syndrome: possible mechanisms of action. Diabetes Metab Syndr Obes. 2018;11:699-705. Review. PMID: 30519065.

        GlucoVantage® is a registered trademark of Nanjing Nutrabuilding Bio-Tech Co.